Formulation and Evaluation of Nanoemugel Transdermal Drug Delivery System of Indomethasin And Piroxicam

Mr. Rithesh P S, Mr. K Sreenath, Mr. Rajashekhar N

Inflammation is a complex process, which is frequently associated with pain and involves occurrences such as the increase of vascular permeability, increase of protein denaturation, and membrane alteration. It is defensive response that is characterized by redness, pain, heat, and swelling and loss of function in the injured area. The most common causes of inflammation are infections, burns and trauma, and many types of immune reactions. Indomethacin and Piroxicam are a potent nonsteroidal anti-inflammatory drug with broad applications. The drug inhibits prostaglandin synthesis produced by cyclooxygenase enzymes, which are critical mediators of inflammation, fever, and pain. Indomethacin is approved by the US Food and Drug Administration (FDA) to manage acute pain, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, bursitis, gouty arthritis, and patent ductus arteriosus
Gel formulation provides better application property and stability in comparison to cream and ointment .topical application of drug offers the advantages of delivering the drug directly to the site of action and acting for an extended period of time. The purpose of this study was to formulate and evaluate Indomethacin and Piroxicam topical Nano emugel for the treatment of Inflammation. Topical Nano emugel prolong residence time of drugs, improve bioavailability, and facilitate drug delivery through systemic route With this objective, Indomethacin and Piroxicam Topical Nanoemulgel as a model drug was prepared for the treatment of Inflammation.Nine different formulations of Topical Nano emugel Loaded with Indomethacin and Piroxicam were prepared by dispersion method The formulations were evaluated for physical parameters like: PH, Spread ability, Retention time, viscosity, skin irritancy, Homogeneity, uniformity of weight, drug content, buoyancy time, dissolution, and drug release mechanism. The formulations were optimized on the basis of buoyancy time and in-vitro drug release. The compatibility of the drug, polymers and other excipients were determined by FT- IR Spectroscopy. Results showed that the drug was compatible with polymers and other excipients. The Viscosity (cP) of all formulations was in the range 4560-6230cp. The Spread ability ranged from 19.14-25.43. All formulations are Homogenous with PH of 6-7. Extrudability was found to be in the range of 80-86% The formulation F6 and F9 obtaining Carbopol and Xanthan gum, respectively at the concentration of 40 % showed more than 97 % drug release at the end of 24 hours. All the tablet formulations followed non-Fickian mechanism of drug release. The stability studies were carried out for 3 months and result indicates that the selected formulation were stable throughout study period. The present study shows that oil phase oleic acid, emulsifiers like tween 20 and PEG 400 are suitable to form stable emulsion in the proportion of 3:1 Carbopol and Xanthan gum combination as gelling agent can be used to develop Nano emugel formulation of Indomethacin and Piroxicam

Keywords: Indomethacin, piroxicam, NSAIDS, Nanoemugel, Topical application, Buoyancy time, Carbopol and Xanthan gum.